"Magnetic Response of Functionalized Lipid Bilayers "

Who: Joachim Kohlbrecher (Paul Scherrer Institut, Villigen, Switzerland)

Place: Donostia International Physics Center (DIPC). Paseo Manuel de Lardizabal, 4, Donostia

Date: Tuesday, 13 January 2015, 10:30

Dr. Joachim Kohlbrecher
Paul Scherrer Institut
Villigen, Switzerland


Magnetic Response of Functionalized Lipid Bilayers

Magnetic field effects on biological molecules are rarely observed, due to
the small diamagnetic susceptibility of individual molecules. In
self-assembly systems, such as phospholipid bilayers, where the molecules
are aggregated parallel to each other, the anisotropy of the diamagnetic
susceptibility become additive and a magnetic orientation in a magnetic
field becomes possible. A well-known system, where this magnetic orientation
has been exploited, is a bicellar mixture of long and short chain
phospholipids used in NMR studies of transmembrane proteins. By doping these
aggregates with paramagnetic lanthanides conferring a large magnetic moment,
the responsiveness to magnetic fields can be enhanced. The effect of
magnetic fields on phospholipid vesicles and bicelles containing a
chelator-lipid with complexed paramagnetic lanthanides will be shown.
Another route to add magnetic response to lipid bilayers is to incorporate
ferromagnetic nanoparticles into them. We succeeded to implement iron oxide
nanoparticles into the membrane of a lipid vesicle to control the release
through magnetic actuation.

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