"Human-induced pluripotent stem cell for regenerative medicine and drug discovery"

Who: Kiyoshi Ohnuma, Nagaoka University of Technology, Japan

Place: nanoGUNE seminar room, Tolosa Hiribidea 76, Donostia - San Sebastian

Date: Monday, 23 March 2015, 11:00

How can a full-scale movable robot being built using Lego bricks? Stem cell researchers face more difficult problems than building a full-scale robot. Pluripotent stem cells can multiply almost infinitely (self-renewal) and differentiate into all cell types (pluripotency). Moreover, Human inducedPluripotent Stem Cells (hiPSCs) can be generated easily, multiply almost infinitely, and can differentiate into various cell types.

 

As a recent result heart tissue that contracted spontaneously was regenerated from stem cells (regenerative medicine) and personalized drugs can be used to treat heart diseases (drug screening).

 

However, many questions must be answered before to achieve the goal of regenerating functional organs. For example, how can large 3D organs (~100 mm) be assembled using small cells (~10 ?m)? This issue is more challenging than building a full-scale movable super-robot such as Mazinger Z (18 m height) made of Lego bricks (~10 mm).

 

In this seminar, I will introduce our recent research on hiPSC-based cell patterning and harvesting techniques based on a microfluidic perfusion culture system.

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